TSAI LABORATORY
ALL PUBLICATIONS

2024

  • Tsai JM, Nowak RP, Ebert BL, Fischer ES. Targeted protein degradation: from mechanisms to clinic. Nat Rev Mol Cell Biol. 2024 Sep;25(9):740-757. PMID: 38684868.

2023

  • Tsai JM, Aguirre JD, Li YD, Brown J, Focht V, Kater L, Kempf G, Sandoval B, Schmitt S, Rutter JC, Galli P, Sandate CR, Cutler JA, Zou C, Donovan KA, Lumpkin RJ, Cavadini S, Park PMC, Sievers Q, Hatton C, Ener E, Regalado BD, Sperling MT, Słabicki M, Kim J, Zon R, Zhang Z, Miller PG, Belizaire R, Sperling AS, Fischer ES, Irizarry R, Armstrong SA, Thomä NH, Ebert BL. UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Mol Cell. 2023 Aug 3;83(15):2753-2767.e10. PMID: 37478846. PMC11134608.
  • Zou C, Yoon H, Park PMC, Patten JJ, Pellman J, Carreiro J, Tsai JM, Li YD, Roy Burman SS, Donovan KA, Gasser J, Sperling AS, Nowak RP, Fischer ES, Davey RA, Ebert BL, Słabicki M. The human E3 ligase RNF185 is a regulator of the SARS- CoV-2 envelope protein. iScience. 2023 May 19;26(5):106601. PMID: 37095859. PMC10082641.
  • Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Lumpkin R, Sandoval B, Jin CY, Ficarro SB, Wang MY, Xu S, Groendyke BJ, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL. Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528208. PMID: 36824856. PMC9949066.

Older Selected Publications

  • Tsai JM, Hata AN, Lennerz JK. MET D1228N and D1246N are the Same Resistance Mutation in MET Exon 14 Skipping. Oncologist. 2021 Dec;26(12):e2297-e2301. PMID: 34347347. PMC8649016.
  • Tsai JM, Tolan NV, Petrides AK, Kanjilal S, Brigl M, Lindeman NI, Li YD, Tanasijevic MJ, Basu SS, Melanson SEF. How SARS-CoV-2 Transformed the Clinical Laboratory: Challenges and Lessons Learned. J Appl Lab Med. 2021 Sep 1;6(5):1338-1354.  PMID: 33822967. PMC8083381.
  • Słabicki M, Yoon H, Koeppel J, Nitsch L, Roy Burman SS, Di Genua C, Donovan KA, Sperling AS, Hunkeler M, Tsai JM, Sharma R, Guirguis A, Zou C, Chudasama P, Gasser JA, Miller PG, Scholl C, Fröhling S, Nowak RP, Fischer ES, Ebert BL. Small-molecule-induced polymerization triggers degradation of BCL6. Nature. 2020 Dec;588(7836):164-168. PMID:33208943. PMC7816212.
  • Tsai JM, Shoham M, Fernhoff NB, George BM, Marjon KD, McCracken MN, Kao KS, Sinha R, Volkmer AK, Miyanishi M, Seita J, Rinkevich Y, Weissman IL. Neutrophil and monocyte kinetics play critical roles in mouse peritoneal adhesion formation. Blood Adv. 2019 Sep 24;3(18):2713-2721. PMID: 31519647. PMC6759736.
  • Tsai JM, Sinha R, Seita J, Fernhoff N, Christ S, Koopmans T, Krampitz GW, McKenna KM, Xing L, Sandholzer M, Sales JH, Shoham M, McCracken M, Joubert LM, Gordon SR, Poux N, Wernig G, Norton JA, Weissman IL, Rinkevich Y. Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers. Sci Transl Med. 2018 Nov 28;10(469):eaan6735. PMID: 30487249.
  • Tsai JM, Weissman IL, Rinkevich Y. Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration. J Vis Exp. 2018 May 31;(135):57302. PMID: 29912198. PMC6101439.
  • Tsai JM, Koh PW, Stefanska A, Xing L, Walmsley GG, Poux N, Weissman IL, Rinkevich Y. Localized hepatic lobular regeneration by central-vein-associated lineage-restricted progenitors. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3654-3659. PMID: 28330992. PMC5389277.
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